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Version: 17.06d (Release date: 2017-06-26)
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CD20-targeted Polypeptide TRU-015 (Code C70797)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: CD20-targeted Polypeptide TRU-015

Definition: A proprietary antibody-based single-chain polypeptide with B cell-depleting activity. Significantly smaller than a whole antibody, CD20-targeted polypeptide TRU-015 binds specifically to the B cell-specific cell surface antigen CD20 with full immunoglobulin Fv fragment-type target binding activity and full immunoglobulin Fc fragment-type effector function. This agent transiently depletes CD20-bearing B cells by inducing B cell -directed complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) and B cell apoptosis.

Label: CD20-targeted Polypeptide TRU-015

NCI Thesaurus Code: C70797 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL375944  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CD20-targeted Polypeptide TRU-015
TRU-015

External Source Codes: 
FDA UNII Code T0N62K2M2Y
PDQ Closed Trial Search ID 570533
PDQ Open Trial Search ID 570533 (check for NCI PDQ open clinical trial info)
NCI META CUI CL375944

Other Properties:
     Name Value (qualifiers indented underneath)
code C70797
Contributing_Source FDA
Legacy_Concept_Name CD20-targeted_Compound_TRU-015
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C70797

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