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Version: 17.12d (Release date: 2017-12-26)
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Ramucirumab (Code C70792)

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Terms & Properties

Preferred Name: Ramucirumab

Definition: A recombinant, fully human monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2) with antiangiogenesis activity. Ramucirumab specifically binds to and inhibits VEGFR-2, which may result in an inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells.

NCI-GLOSS Definition: A substance being studied in the treatment of breast cancer that has come back. It binds to receptors for a protein called vascular endothelial growth factor (VEGF). This keeps VEGF from binding to the receptors and may stop the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent and a type of monoclonal antibody.

Display Name: Ramucirumab

Label: Ramucirumab

NCI Thesaurus Code: C70792 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2742502  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
anti-VEGFR-2 fully human monoclonal antibody IMC-1121B
Anti-VEGFR-2 Fully Human Monoclonal Antibody IMC-1121B
Monoclonal Antibody HGS-ETR2

External Source Codes: 
CAS Registry Number 947687-13-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 570535
PDQ Open Trial Search ID 570535 (check for NCI PDQ open clinical trial info)
UMLS CUI C2742502

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For metastatic colorectal cancer (mCRC); advanced or metastatic, gastric or gastroesophageal junction (GEJ) adenocarcinoma
Accepted_Therapeutic_Use_For multicentric Castleman's disease (MCD)
code C70792
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-VEGFR-2_Fully_Human_Monoclonal_Antibody_IMC-1121B
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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