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Version: 17.12d (Release date: 2017-12-26)
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Obinutuzumab (Code C70741)

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Terms & Properties

Preferred Name: Obinutuzumab

Definition: A glycoengineered, humanized IgG1 monoclonal antibody with potential antineoplastic activity. Obinutuzumab, a third generation type II anti-CD20 antibody, selectivity binds to the extracellular domain of the human CD20 antigen on malignant human B cells. The Fc region carbohydrates of the antibody, enriched in bisected non-fucosylated glycosylation variants, contribute to its higher binding affinity for human FcgammaRIII receptors compared to non-glycoengineered antibodies, resulting in enhanced antibody-dependent cellular cytotoxicity (ADCC) and caspase-independent apoptosis. In addition, modification of elbow hinge sequences within the antibody variable framework regions may account for the strong apoptosis-inducing activity of R7159 upon binding to CD20 on target cells.

Display Name: Obinutuzumab

Label: Obinutuzumab

NCI Thesaurus Code: C70741 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2742503  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD20 Monoclonal Antibody R7159
RO 5072759

External Source Codes: 
CAS Registry Number 949142-50-1 (see NLM ChemIDplus info)
FDA UNII Code O43472U9X8
PDQ Closed Trial Search ID 570643
PDQ Open Trial Search ID 570643 (check for NCI PDQ open clinical trial info)
UMLS CUI C2742503

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For follicular lymphoma (FL); chronic lymphocytic leukemia
code C70741
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-CD20_Monoclonal_Antibody_R7159
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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