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Version: 17.06d (Release date: 2017-06-26)
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Gadobutrol (Code C70675)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Gadobutrol

Definition: A gadolinium-based, hydrophilic, macrocyclic, electrically neutral contrast agent used in contrast-enhanced MRI (CE-MRI). Gadobutrol is a non-ionic, paramagnetic complex consisting of gadolinium (Gd3+) chelated with the macrocyclic compound dihydroxy-hydroxymethylpropyl-tetraazacyclododecane-triacetic acid (butrol). Following intravenous administration, gadobutrol may increase MRI sensitivity for the detection of tumors and inflammatory and demyelinating diseases of the central nervous system (CNS) that are associated with areas with blood-brain barrier defects due to altered perfusion or an enlarged extracellular space. This agent is eliminated in an unchanged form via the kidneys; extra-renal elimination is negligible.

Display Name: Gadobutrol

Label: Gadobutrol

NCI Thesaurus Code: C70675 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0291216  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(10-((1RS,2SR)-2,3-Dihydroxy-1-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-))gadolinium
BAY86-4875
Gadavist
Gadobutrol
GADOBUTROL
Gadograf
Gadovist
Protovis
ZK 135079

External Source Codes: 
CAS Registry Number 138071-82-6 (see NLM ChemIDplus info)
FDA UNII Code 1BJ477IO2L
PDQ Closed Trial Search ID 570641
PDQ Open Trial Search ID 570641 (check for NCI PDQ open clinical trial info)
UMLS CUI C0291216

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Diagnostic Magnetic Resonance Imaging
Chemical_Formula C18H31N4O9.Gd
code C70675
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Gadobutrol
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C70675

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