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Version: 17.06d (Release date: 2017-06-26)
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Erastin Analogue PRLX 93936 (Code C70625)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Erastin Analogue PRLX 93936

Definition: A structural analogue of erastin with potential antineoplastic activity. Erastin analogue PRLX 93936 appears to inhibit mitochondrial outer membrane protein VDACs (voltage-dependent anion channels) 2 and 3, resulting in an oxidative, non-apoptotic cell death. Erastin analogue PRLX 93936 exhibits greater lethality in cell lines harboring mutations in the GTPase protein oncogenes HRAS and KRAS or the serine-threonine protein kinase oncogene BRAF than in non-tumorigenic cell lines. VDACs 2 and 3 are up-regulated in a wide variety of tumor cell lines.

Display Name: Erastin Analogue PRLX 93936

Label: Erastin Analogue PRLX 93936

NCI Thesaurus Code: C70625 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL375988  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Erastin Analogue PRLX 93936
PRLX 93936

External Source Codes: 
PDQ Closed Trial Search ID 570728
PDQ Open Trial Search ID 570728 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 17568748 (see PubMed Primary Reference info)
NCI META CUI CL375988

Other Properties:
     Name Value (qualifiers indented underneath)
code C70625
Contributing_Source CTRP
Legacy_Concept_Name Erastin_Analogue_PRLX93936
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C70625

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