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Version: 17.06d (Release date: 2017-06-26)
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Ceftobiprole Medocaril (Code C70597)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ceftobiprole Medocaril

Definition: A water-soluble prodrug of ceftobiprole, a pyrrolidinone cephalosporin antibiotic, with bactericidal activity. Ceftobiprole binds to and inactivates penicillin-binding proteins (PBPs), enzymes involved in the terminal stages of bacterial cell wall assembly and cell wall reshaping during bacterial growth and division. This agent exhibits a broad spectrum of activity against gram-negative and gram-positive pathogens including methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA). Ceftobiprole is refractory to hydrolysis by class A and class C lactamases.

Label: Ceftobiprole Medocaril

NCI Thesaurus Code: C70597 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1622308  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BAL5788
Ceftobiprole Medocaril
CEFTOBIPROLE MEDOCARIL
JNJ30982081
RO 65-5788

External Source Codes: 
CAS Registry Number 252188-71-9 (see NLM ChemIDplus info)
FDA UNII Code N99027V28J
PDQ Closed Trial Search ID 570771
PDQ Open Trial Search ID 570771 (check for NCI PDQ open clinical trial info)
UMLS CUI C1622308

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H25N8O11S2.Na
code C70597
Contributing_Source FDA
Legacy_Concept_Name Ceftobiprole_Medocaril
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C70597

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