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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18 Fluoroethylcholine (Code C70594)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorine F 18 Fluoroethylcholine

Definition: Ethylcholine labeled with fluorine F 18, a positron-emitting isotope. Fluorine F 18 fluoroethylcholine incorporates into tumor cells through an active, carrier-mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, yielding a phosphoryl derivative, and finally is integrated into cellular phospholipids, probably primarily into a phosphatidyl derivative; concentration of this agent in tumor cells as various fluorine F 18 fluoroethylcholine derivatives enables tumor imaging using positron emission tomography (PET). Choline kinase, the enzyme responsible for the phosphorylation of choline, is frequently up-regulated in human tumor cell lines.

Display Name: Fluorine F 18 Fluoroethylcholine

Label: Fluorine F 18 Fluoroethylcholine

NCI Thesaurus Code: C70594 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL375797  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18F-Fluoroethylcholine
Fluorine F 18 Fluoroethylcholine
FLUOROETHYLCHOLINE ION F-18

External Source Codes: 
CAS Registry Number 188709-02-6 (see NLM ChemIDplus info)
FDA UNII Code 290587400Z
PDQ Closed Trial Search ID 570770
PDQ Open Trial Search ID 570770 (check for NCI PDQ open clinical trial info)
NCI META CUI CL375797

Other Properties:
     Name Value (qualifiers indented underneath)
code C70594
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fluorine_18_Ethylcholine
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C70594

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