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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18 Fluoroethylcholine (Code C70594)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorine F 18 Fluoroethylcholine

Definition: Ethylcholine labeled with fluorine F 18, a positron-emitting isotope. Fluorine F 18 fluoroethylcholine incorporates into tumor cells through an active, carrier-mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, yielding a phosphoryl derivative, and finally is integrated into cellular phospholipids, probably primarily into a phosphatidyl derivative; concentration of this agent in tumor cells as various fluorine F 18 fluoroethylcholine derivatives enables tumor imaging using positron emission tomography (PET). Choline kinase, the enzyme responsible for the phosphorylation of choline, is frequently up-regulated in human tumor cell lines.

Display Name: Fluorine F 18 Fluoroethylcholine

Label: Fluorine F 18 Fluoroethylcholine

NCI Thesaurus Code: C70594 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL375797  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fluorine F 18 Fluoroethylcholine

External Source Codes: 
CAS Registry Number 188709-02-6 (see NLM ChemIDplus info)
FDA UNII Code 290587400Z
PDQ Closed Trial Search ID 570770
PDQ Open Trial Search ID 570770 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C70594
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fluorine_18_Ethylcholine
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  


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