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Version: 16.11d (Release date: 2016-11-28)
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Norethindrone Acetate (Code C702)

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Terms & Properties

Preferred Name: Norethindrone Acetate

Definition: The orally bioavailable acetate salt of norethindrone, a synthetic progestin with some anabolic, estrogenic, and androgenic activities. As do all progestins, norethindrone binds to and activates nuclear progesterone receptors (PRs) in target tissues such as the pituitary and reproductive system; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes, followed by various transcriptional events and histone acetylation. Physiological effects include the inhibition of luteinizing hormone (LH) release, an increase in the endometrial luteal-phase, and alterations in endocervical mucus secretion.

Label: Norethindrone Acetate

NCI Thesaurus Code: C702 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0699165  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aygestin
Nor-Q.D.
NORETHINDRONE ACETATE
Norethindrone Acetate
Norethindrone acetate
Norethisterone Acetate
Norethisterone acetate
Norlutate
Ortho Micronor

External Source Codes: 
CAS Registry Number 51-98-9 (see NLM ChemIDplus info)
FDA UNII Code 9S44LIC7OJ
NSC Code 9564 (see NCI DTP info)
PDQ Closed Trial Search ID 39254
PDQ Open Trial Search ID 39254 (check for NCI PDQ open clinical trial info)
UMLS CUI C0699165

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C22H28O3
code C702
Contributing_Source FDA
Legacy_Concept_Name Norethindrone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C702

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