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Version: 17.06d (Release date: 2017-06-26)
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Masoprocol (Code C701)

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Terms & Properties

Preferred Name: Masoprocol

Definition: A naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. Masoprocol directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, masoprocol inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrienes. It may prevent leukocyte infiltration into tissues and the release of reactive oxygen species.

NCI-GLOSS Definition: A drug put on the skin to treat growths caused by sun exposure. A form of Masoprocol that is taken by mouth is being studied in the treatment of prostate cancer. Masoprocol is an antioxidant, and it may block certain enzymes needed for tumor growth.

Display Name: Masoprocol

Label: Masoprocol

NCI Thesaurus Code: C701 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0733397  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]
Actinex
Masoprocol
MASOPROCOL
masoprocol
NDGA
NDHGA
Nordihydroguaiaretic Acid
Nordihydroguaiaretic acid

External Source Codes: 
CAS Registry Number 27686-84-6 (see NLM ChemIDplus info)
FDA UNII Code 7BO8G1BYQU
NSC Code 4291 (see NCI DTP info)
PDQ Closed Trial Search ID 479648
PDQ Open Trial Search ID 479648 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 8450672 (see PubMed Primary Reference info)
UMLS CUI C0733397

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H22O4
code C701
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Nordihydroguaiaretic_Acid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C701

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