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Version: 17.06d (Release date: 2017-06-26)
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Nimustine (Code C693)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nimustine

Definition: A nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. (NCI05)

NCI-GLOSS Definition: A substance that is being studied in the treatment of brain cancer. It belongs to the family of drugs called nitrosoureas.

Label: Nimustine

NCI Thesaurus Code: C693 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0028096  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea
ACNU
N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea
Nidran
NIMUSTINE
Nimustine
nimustine

External Source Codes: 
CAS Registry Number 42471-28-3 (see NLM ChemIDplus info)
FDA UNII Code 0S726V972K
NSC Code 245382 (see NCI DTP info)
PDQ Closed Trial Search ID 38853
PDQ Open Trial Search ID 38853 (check for NCI PDQ open clinical trial info)
UMLS CUI C0028096

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H13ClN6O2
code C693
Contributing_Source FDA
Legacy_Concept_Name Nimustine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C693

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