skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.11d (Release date: 2016-11-28)
SearchBox Top
SearchBox Bottom
Nimodipine (Code C692)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nimodipine

Definition: A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents.

NCI-GLOSS Definition: Belongs to a family of drugs called calcium channel blockers. It is being investigated for use with anticancer drugs to prevent or overcome drug resistance and improve response to chemotherapy.

Label: Nimodipine

NCI Thesaurus Code: C692 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0678207  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
NIMO
NIMODIPINE
Nimodipine
nimodipine
Nimotop

External Source Codes: 
CAS Registry Number 66085-59-4 (see NLM ChemIDplus info)
FDA UNII Code 57WA9QZ5WH
ChEBI ID CHEBI:7575 (see ChEBI info)
PDQ Closed Trial Search ID 41210
PDQ Open Trial Search ID 41210 (check for NCI PDQ open clinical trial info)
UMLS CUI C0678207

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C21H26N2O7
code C692
Contributing_Source FDA
Legacy_Concept_Name Nimodipine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C692

Mainbox Bottom