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Version: 17.06d (Release date: 2017-06-26)
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Mast Cell Stabilizer TF002 (Code C69146)

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Terms & Properties

Preferred Name: Mast Cell Stabilizer TF002

Definition: A small molecule with mast cell stabilizing activity. Mast cell stabilizer TF002 inhibits the formation of lipid rafts of mast cell membranes that contain the signaling machinery which triggers the release of mast cell allergic and inflammatory mediators. Inhibition of lipid raft assembly by this agent results in mast cell stabilization, preventing mast cell degranulation and the release of the inflammatory mediators involved in type I allergic reactions (histamine, leukotrienes, prostaglandins, and cytokines). The assembly of the signaling machinery in mast cell lipid rafts, specialized membrane microdomains rich in cholesterol and sphingolipids, is initiated by IgE binding to its receptor on the mast cell surface; subsequently, allergens crosslink with the IgE/receptor complex and other proteins and lipids are recruited into the signaling machinery.

Label: Mast Cell Stabilizer TF002

NCI Thesaurus Code: C69146 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL375376  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Mast Cell Stabilizer TF002
TF002

External Source Codes: 
PDQ Closed Trial Search ID 547030
PDQ Open Trial Search ID 547030 (check for NCI PDQ open clinical trial info)
NCI META CUI CL375376

Other Properties:
     Name Value (qualifiers indented underneath)
code C69146
Legacy_Concept_Name Mast_Cell_Stabilizer_TF002
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69146

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