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Version: 17.06d (Release date: 2017-06-26)
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MEK Inhibitor AZD8330 (Code C69143)

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Terms & Properties

Preferred Name: MEK Inhibitor AZD8330

Definition: An orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

Display Name: MEK Inhibitor AZD8330

Label: MEK Inhibitor AZD8330

NCI Thesaurus Code: C69143 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346908  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MEK Inhibitor AZD8330

External Source Codes: 
PDQ Closed Trial Search ID 543526
PDQ Open Trial Search ID 543526 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346908

Other Properties:
     Name Value (qualifiers indented underneath)
code C69143
Contributing_Source CTRP
Legacy_Concept_Name MEK_Inhibitor_AZD8330
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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