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Version: 17.06d (Release date: 2017-06-26)
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D-methionine Formulation MRX-1024 (Code C69140)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: D-methionine Formulation MRX-1024

Definition: A proprietary oral formulation of D-methionine with antioxidant and antimucositis activities. D-methionine formulation MRX-1024 may selectively protect the oral mucosa from the toxic effects of chemotherapy and radiation therapy without compromising antitumor activity. D-methionine may be converted into the L- isomer in vivo, particularly in instances of L-methionine deprivation; both isomers have antioxidant activity which may be due, in part, to their sulfur moieties and chelating properties. L-methionine, an essential amino acid, also may help to maintain the ratio of reduced glutathione to oxidized glutathione in cells undergoing oxidative stress and may provide a source of L-cysteine for glutathione synthesis.

Label: D-methionine Formulation MRX-1024

NCI Thesaurus Code: C69140 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL371849  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
D-methionine Formulation MRX-1024
MRX-1024

External Source Codes: 
PDQ Closed Trial Search ID 540244
PDQ Open Trial Search ID 540244 (check for NCI PDQ open clinical trial info)
NCI META CUI CL371849

Other Properties:
     Name Value (qualifiers indented underneath)
code C69140
Legacy_Concept_Name D-methionine_Formulation_MRX-1024
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69140

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