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Version: 17.06d (Release date: 2017-06-26)
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Hsp90 Antagonist KW-2478 (Code C69139)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hsp90 Antagonist KW-2478

Definition: An agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition of cell proliferation, and the induction of apoptosis in tumor cells. HSP90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses.

Display Name: Hsp90 Antagonist KW-2478

Label: Hsp90 Antagonist KW-2478

NCI Thesaurus Code: C69139 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348995  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hsp90 Antagonist KW-2478
KW-2478

External Source Codes: 
PDQ Closed Trial Search ID 548017
PDQ Open Trial Search ID 548017 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348995

Other Properties:
     Name Value (qualifiers indented underneath)
code C69139
Contributing_Source CTRP
Legacy_Concept_Name Hsp90_Antagonist_KW-2478
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69139

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