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Version: 17.06d (Release date: 2017-06-26)
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RAF Kinase Inhibitor XL281 (Code C69135)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: RAF Kinase Inhibitor XL281

Definition: An orally active, small molecule with potential antineoplastic activity. XL281 specifically inhibits RAF kinases, located downstream from RAS in the RAS/RAF/MEK/ERK kinase signaling pathway, which may result in reduced proliferation of tumor cells. RAS mutations may result in constitutive activation of the RAS/RAF/MEK/ERK kinase signaling pathway, and have been found to occur frequently in human tumors.

Display Name: RAF Kinase Inhibitor XL281

Label: RAF Kinase Inhibitor XL281

NCI Thesaurus Code: C69135 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL371855  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
RAF Kinase Inhibitor XL281
XL281

External Source Codes: 
PDQ Closed Trial Search ID 543515
PDQ Open Trial Search ID 543515 (check for NCI PDQ open clinical trial info)
NCI META CUI CL371855

Other Properties:
     Name Value (qualifiers indented underneath)
code C69135
Contributing_Source CTRP
Legacy_Concept_Name RAF_Kinase_Inhibitor_XL281
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69135

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