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Version: 17.06d (Release date: 2017-06-26)
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Pasireotide (Code C69131)

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Terms & Properties

Preferred Name: Pasireotide

Definition: A synthetic long-acting cyclic peptide with somatostatin-like activity. Pasireotide activates a broad spectrum of somatostatin receptors, exhibiting a much higher binding affinity for somatostatin receptors 1, 3, and 5 than octreotide in vitro, as well as a comparable binding affinity for somatostatin receptor 2. This agent is more potent than somatostatin in inhibiting the release of human growth hormone (HGH), glucagon, and insulin.

Display Name: Pasireotide

Label: Pasireotide

NCI Thesaurus Code: C69131 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1872203  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L-phenylalanyl-)
Pasireotide
PASIREOTIDE
SOM230

External Source Codes: 
CAS Registry Number 396091-73-9 (see NLM ChemIDplus info)
FDA UNII Code 98H1T17066
PDQ Closed Trial Search ID 540440
PDQ Open Trial Search ID 540440 (check for NCI PDQ open clinical trial info)
UMLS CUI C1872203

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C58H66N10O9
code C69131
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pasireotide
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69131

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