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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Nematode Anticoagulant Protein c2 (Code C69129)

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Terms & Properties

Preferred Name: Recombinant Nematode Anticoagulant Protein c2

Definition: An 85-amino acid recombinant peptide derived from protein c2 of the hemophagocytic hookworm Ancylostoma caninum (a common canine parasite) with anticoagulant activity. Recombinant nematode anticoagulant protein c2 (rNAPc2) binds to circulating activated factor X (FXa) or zymogen factor X (FX) to form a binary complex which subsequently binds to and inhibits membrane-bound activated factor VII/tissue factor complex (FVIIa/TF). When administered prophylactically, this agent may reduce the incidence of deep venous thrombosis without hemostatic compromise. Because rNAPc2 inhibits the formation of the FVIIa/TF protease complex, which may play a role in the cellular signaling of both metastatic and angiogenic processes, it may impede tumor progression.

Label: Recombinant Nematode Anticoagulant Protein c2

NCI Thesaurus Code: C69129 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL371851  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Nematode Anticoagulant Protein c2
rNAPc2

External Source Codes: 
PDQ Closed Trial Search ID 540319
PDQ Open Trial Search ID 540319 (check for NCI PDQ open clinical trial info)
NCI META CUI CL371851

Other Properties:
     Name Value (qualifiers indented underneath)
code C69129
Legacy_Concept_Name Recombinant_Nematode_Anticoagulant_Protein_c2
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69129

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