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Version: 17.06d (Release date: 2017-06-26)
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Fostamatinib Disodium (Code C69128)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fostamatinib Disodium

Definition: An orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer and certain other diseases, such as rheumatoid arthritis. It may block tumor cell signaling and growth. It is a type of tyrosine kinase inhibitor.

Display Name: Fostamatinib Disodium

Label: Fostamatinib Disodium

NCI Thesaurus Code: C69128 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL375266  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]- 4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, Disodium Salt, Hexahydrate
Fostamatinib Disodium
FOSTAMATINIB DISODIUM
R-935788 Sodium
R788 Sodium
R788 sodium
Syk kinase inhibitor R-935788
SYK Kinase Inhibitor R-935788

External Source Codes: 
CAS Registry Number 914295-16-2 (see NLM ChemIDplus info)
FDA UNII Code 86EEZ49YVB
NSC Code 365798 (see NCI DTP info)
PDQ Closed Trial Search ID 540197
PDQ Open Trial Search ID 540197 (check for NCI PDQ open clinical trial info)
NCI META CUI CL375266

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H24FN6O9P.2Na.6H2O
code C69128
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name SYK_Kinase_Inhibitor_R-935788
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69128

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