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Version: 17.06d (Release date: 2017-06-26)
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Nicotine (Code C691)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nicotine

Definition: A plant alkaloid, found in the tobacco plant, and addictive central nervous system (CNS) stimulant that causes either ganglionic stimulation in low doses or ganglionic blockage in high doses. Nicotine acts as an agonist at the nicotinic cholinergic receptors in the autonomic ganglia, at neuromuscular junctions, and in the adrenal medulla and the brain. Nicotine's CNS-stimulating activities may be mediated through the release of several neurotransmitters, including acetylcholine, beta-endorphin, dopamine, norepinephrine, serotonin, and ACTH. As a result, peripheral vasoconstriction, tachycardia, and elevated blood pressure may be observed with nicotine intake. This agent may also stimulate the chemoreceptor trigger zone, thereby inducing nausea and vomiting.

NCI-GLOSS Definition: An addictive, poisonous chemical found in tobacco. It can also be made in the laboratory. When it enters the body, nicotine causes an increased heart rate and use of oxygen by the heart, and a sense of well-being and relaxation. It is also used as an insecticide.

Display Name: Nicotine

Label: Nicotine

NCI Thesaurus Code: C691 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0028040  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-Nicotine
(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
1-Methyl-2-(3-pyridyl)pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
NIC
Nicotine
NICOTINE
nicotine

External Source Codes: 
CAS Registry Number 54-11-5 (see NLM ChemIDplus info)
FDA UNII Code 6M3C89ZY6R
ChEBI ID CHEBI:17688 (see ChEBI info)
NSC Code 5065 (see NCI DTP info)
PDQ Closed Trial Search ID 42243
PDQ Open Trial Search ID 42243 (check for NCI PDQ open clinical trial info)
UMLS CUI C0028040

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Smoking Cessation
Chemical_Formula C10H14N2
code C691
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Nicotine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C691

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