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Version: 17.06d (Release date: 2017-06-26)
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Rindopepimut (Code C69076)

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Terms & Properties

Preferred Name: Rindopepimut

Definition: A cancer vaccine consisting of a human epidermal growth factor receptor variant III (EGFRvIIi)-specific peptide conjugated to the non-specific immunomodulator keyhole limpet hemocyanin (KLH) with potential antineoplastic activity. Vaccination with anti-EGFRvIII vaccine CDX-110 may elicit a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing EGFRvIII. EGFRvIII, a functional variant of EGFR that is not expressed in normal tissues, was originally discovered in glioblastoma multiforme (GBM) and has also been found in various other cancers such as breast, ovarian, metastatic prostate, colorectal, and head and neck cancers. EGFRvIII contains an 83 amino acid deletion in its extracellular domain and has been shown to transform NIH/3T3 mouse embryonic fibroblast cells in vitro.

Display Name: Rindopepimut

Label: Rindopepimut

NCI Thesaurus Code: C69076 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3181262  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-EGFRvIII Vaccine CDX-110
CDX-110
L-Cysteine, L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-lysylglycyl-L-asparaginyl-L-tyrosyl-L-valyl-L-valyl-L-threonyl-L-alpha-aspartyl-L-histidyl-S-(1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)-, complex with hemocyanin (Megathura crenulata)
PF-04948568
Rindopepimut

External Source Codes: 
CAS Registry Number 946156-74-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 546970
PDQ Open Trial Search ID 546970 (check for NCI PDQ open clinical trial info)
UMLS CUI C3181262

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Immunotherapy for glioblastoma multiforme
code C69076
Contributing_Source CTRP
Legacy_Concept_Name Anti-EGFRvIII_Vaccine_CDX-110
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69076

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