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Version: 16.11d (Release date: 2016-11-28)
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Sialyl Lewis-Keyhole Limpet Hemocyanin Conjugate Vaccine (Code C69000)

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Terms & Properties

Preferred Name: Sialyl Lewis-Keyhole Limpet Hemocyanin Conjugate Vaccine

Definition: A vaccine consisting of the oligosaccharide antigen sialyl Lewis (CA19-9) conjugated to the nonspecific immunomodulator keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Upon administration, sialyl Lewis-keyhole limpet hemocyanin conjugate vaccine may induce production of IgG and IgM antibodies as well as trigger an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing the sialyl Lewis antigen. Sialyl Lewis is a blood group antigen and a tumor-associated antigen associated with epithelial cancers such as breast cancer and various digestive cancers. Sialyl Lewis serves as a ligand for the cytokine-inducible cell adhesion molecule (CAM) E-selectin, an endothelial cell-specific type I transmembrane surface protein, thus facilitating hematogenous metastasis by mediating the adhesion of circulating cancer cells to vascular endothelium.

Label: Sialyl Lewis-Keyhole Limpet Hemocyanin Conjugate Vaccine

NCI Thesaurus Code: C69000 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL375271  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Sialyl Lewis-Keyhole Limpet Hemocyanin Conjugate Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 544559
PDQ Open Trial Search ID 544559 (check for NCI PDQ open clinical trial info)
NCI META CUI CL375271

Other Properties:
Name Value (qualifiers indented underneath)
code C69000
Legacy_Concept_Name Sialyl_Lewis-Keyhole_Limpet_Hemocyanin_Conjugate_Vaccine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C69000

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