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Version: 17.06d (Release date: 2017-06-26)
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Serine/Threonine Kinase Inhibitor XL418 (Code C68963)

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Terms & Properties

Preferred Name: Serine/Threonine Kinase Inhibitor XL418

Definition: A selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.

Label: Serine/Threonine Kinase Inhibitor XL418

NCI Thesaurus Code: C68963 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL374493  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Serine/Threonine Kinase Inhibitor XL418

External Source Codes: 
PDQ Closed Trial Search ID 546978
PDQ Open Trial Search ID 546978 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C68963
Legacy_Concept_Name Serine_Threonine_Kinase_Inhibitor_XL418
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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