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Version: 17.06d (Release date: 2017-06-26)
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Therapeutic Angiotensin-(1-7) (Code C68962)

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Terms & Properties

Preferred Name: Therapeutic Angiotensin-(1-7)

Definition: A synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phosphorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 MAPK signaling pathway. In the renin-angiotensin system, the vasodilating activity of angiotensin- (1-7), hydrolysed from angiotensin II by the type I transmembrane metallopeptidase and carboxypeptidase angiotensin converting enzyme 2 (ACE2) in vivo, counteracts the vasoconstricting activity of angiotensin II.

NCI-GLOSS Definition: A substance being studied in the treatment of several types of cancer. Therapeutic angiotensin-(1-7) is a hormone that is made in the laboratory, and helps control blood pressure. It may stop the growth of some types of cancer cells and may stop the growth of blood vessels needed by tumors to grow. It is a type of antiproliferative agent.

Display Name: Therapeutic Angiotensin-(1-7)

Label: Therapeutic Angiotensin-(1-7)

NCI Thesaurus Code: C68962 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0103306  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Angiotensin 1-7
Ang 1-7
Therapeutic Angiotensin-(1-7)
therapeutic angiotensin-(1-7)

External Source Codes: 
ChEBI ID CHEBI:55438 (see ChEBI info)
PDQ Closed Trial Search ID 543940
PDQ Open Trial Search ID 543940 (check for NCI PDQ open clinical trial info)
UMLS CUI C0103306

Other Properties:
     Name Value (qualifiers indented underneath)
code C68962
Contributing_Source CTRP
Legacy_Concept_Name Therapeutic_Angiotensin_1-7
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68962

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