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Version: 17.12d (Release date: 2017-12-26)
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Filanesib (Code C68937)

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Terms & Properties

Preferred Name: Filanesib

Definition: A synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.

Display Name: KSP Inhibitor ARRY-520

Label: Filanesib

NCI Thesaurus Code: C68937 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346611  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2S)-
KSP Inhibitor ARRY-520

External Source Codes: 
CAS Registry Number 885060-09-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 546990
PDQ Open Trial Search ID 546990 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346611

Other Properties:
     Name Value (qualifiers indented underneath)
code C68937
Contributing_Source CTRP
Legacy_Concept_Name KSP_Inhibitor_ARRY-520
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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