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Version: 17.04d (Release date: 2017-04-24)
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Quizartinib (Code C68936)

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Terms & Properties

Preferred Name: Quizartinib

Definition: An orally available small molecule with potential antineoplastic activity. Quizartinib selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases.

Display Name: Quizartinib

Label: Quizartinib

NCI Thesaurus Code: C68936 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2980091  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2E)-N-(4-(3-Chloro-4-Fluoroanilino)-7-(((3S)-Oxolan-3-Yl)Oxy)Quinoxazolin-6-yl)-4-(Dimethylamino)but-2-Enamide
AC-220
AC010220
AC220
N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo [2,1-b] [1,3] benzothiazol 2-yl]phenyl}urea
Quizartinib
QUIZARTINIB

External Source Codes: 
CAS Registry Number 950769-58-1 (see NLM ChemIDplus info)
FDA UNII Code 7LA4O6Q0D3
PDQ Closed Trial Search ID 547019
PDQ Open Trial Search ID 547019 (check for NCI PDQ open clinical trial info)
UMLS CUI C2980091

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H32N6O4S
code C68936
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name FLT-3_Kinase_Inhibitor_AC220
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68936

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