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Version: 17.12d (Release date: 2017-12-26)
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Quizartinib (Code C68936)

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Terms & Properties

Preferred Name: Quizartinib

Definition: An orally available small molecule with potential antineoplastic activity. Quizartinib selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases.

Display Name: Quizartinib

Label: Quizartinib

NCI Thesaurus Code: C68936 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2980091  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2E)-N-(4-(3-Chloro-4-Fluoroanilino)-7-(((3S)-Oxolan-3-Yl)Oxy)Quinoxazolin-6-yl)-4-(Dimethylamino)but-2-Enamide
AC-220
AC010220
AC220
N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo [2,1-b] [1,3] benzothiazol 2-yl]phenyl}urea
Quizartinib
QUIZARTINIB

External Source Codes: 
CAS Registry Number 950769-58-1 (see NLM ChemIDplus info)
FDA UNII Code 7LA4O6Q0D3
UMLS CUI C2980091

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H32N6O4S
code C68936
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name FLT-3_Kinase_Inhibitor_AC220
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68936

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