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Version: 17.12d (Release date: 2017-12-26)
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Teglarinad Chloride (Code C68931)

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Terms & Properties

Preferred Name: Teglarinad Chloride

Definition: A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.

Display Name: Teglarinad Chloride

Label: Teglarinad Chloride

NCI Thesaurus Code: C68931 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346839  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CHS828 Prodrug
Pyridinium, 4-[[[[6-(4-chlorophenoxy)hexyl]amino](cyanoamino) methylene]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-, chloride
Teglarinad Chloride

External Source Codes: 
CAS Registry Number 432037-57-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 547816
PDQ Open Trial Search ID 547816 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346839

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H43ClN5O8.Cl
code C68931
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Apoptosis_Inducer_GMX1777
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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