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Version: 17.06d (Release date: 2017-06-26)
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Teglarinad Chloride (Code C68931)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Teglarinad Chloride

Definition: A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.

Display Name: Teglarinad Chloride

Label: Teglarinad Chloride

NCI Thesaurus Code: C68931 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346839  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CHS828 Prodrug
EB1627
GMX1777
Pyridinium, 4-[[[[6-(4-chlorophenoxy)hexyl]amino](cyanoamino) methylene]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-, chloride
Teglarinad Chloride
TEGLARINAD CHLORIDE

External Source Codes: 
CAS Registry Number 432037-57-5 (see NLM ChemIDplus info)
FDA UNII Code D6V5QYX9MZ
PDQ Closed Trial Search ID 547816
PDQ Open Trial Search ID 547816 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346839

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H43ClN5O8.Cl
code C68931
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Apoptosis_Inducer_GMX1777
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68931

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