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Version: 17.12d (Release date: 2017-12-26)
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Therapeutic Estetrol (Code C68928)

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Terms & Properties

Preferred Name: Therapeutic Estetrol

Definition: A synthetic steroid similar or identical to endogenous estetrol, a short-acting estrogen with both agonistic and antagonistic estrogen receptor activity. Administered orally, therapeutic estetrol binds to the estrogen receptor and as a selective estrogen receptor modulator (SERM) exhibits estrogen agonism in certain tissues and estrogen antagonism in others. Displaying weak estrogen activity in the uterus, estetrol acts as an estrogen antagonist in breast tissue. Produced solely by the human fetal liver, endogenous estetrol is the primary estrogen metabolite of estrogen biosynthesis in the human fetal liver.

Label: Therapeutic Estetrol

NCI Thesaurus Code: C68928 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL374508  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Therapeutic E4
Therapeutic Estetrol

External Source Codes: 
PDQ Closed Trial Search ID 549539
PDQ Open Trial Search ID 549539 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C68928
Legacy_Concept_Name Therapeutic_Estetrol
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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