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Version: 17.06d (Release date: 2017-06-26)
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Therapeutic Hemin (Code C68925)

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Terms & Properties

Preferred Name: Therapeutic Hemin

Definition: A sterile, lyophilized powder of hemin, the Fe3+ oxidation product of heme (Fe2+), derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway, resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors. The mechanism by which therapeutic hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been determined.

Label: Therapeutic Hemin

NCI Thesaurus Code: C68925 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0030316  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hematin for Injection
Hemin for Injection
Panhematin
Therapeutic Hemin

External Source Codes: 
PDQ Closed Trial Search ID 549706
PDQ Open Trial Search ID 549706 (check for NCI PDQ open clinical trial info)
UMLS CUI C0030316

Other Properties:
     Name Value (qualifiers indented underneath)
code C68925
Legacy_Concept_Name Therapeutic_Hemin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68925

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