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Version: 16.10e (Release date: 2016-10-31)
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Oral Picoplatin (Code C68924)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oral Picoplatin

Definition: An oral preparation of picoplatin, a third generation platinum compound with antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and RNA transcription and the induction of apoptosis. Because of the increase in steric bulk around the platinum center, there is a relative reduction in the inactivation of picoplatin by thiol-containing species such as glutathione and metallothionein in comparison to cisplatin.

Label: Oral Picoplatin

NCI Thesaurus Code: C68924 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL374343  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oral Picoplatin
Picoplatin (Oral)

External Source Codes: 
PDQ Closed Trial Search ID 551562
PDQ Open Trial Search ID 551562 (check for NCI PDQ open clinical trial info)
NCI META CUI CL374343

Other Properties:
Name Value (qualifiers indented underneath)
code C68924
Legacy_Concept_Name Oral_Picoplatin
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68924

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