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Version: 17.06d (Release date: 2017-06-26)
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Aldoxorubicin (Code C68921)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Aldoxorubicin

Definition: A 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Following intravenous administration, aldoxorubicin binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hypervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity.

Display Name: Aldoxorubicin

Label: Aldoxorubicin

NCI Thesaurus Code: C68921 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3495619  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aldoxorubicin
DOXO-EMCH
Doxorubicin-EMCH
INNO-206

External Source Codes: 
CAS Registry Number 1361644-26-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 552648
PDQ Open Trial Search ID 552648 (check for NCI PDQ open clinical trial info)
UMLS CUI C3495619

Other Properties:
     Name Value (qualifiers indented underneath)
code C68921
Contributing_Source CTRP
Legacy_Concept_Name Doxorubicin_Prodrug_INNO-206
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68921

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