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Version: 17.06d (Release date: 2017-06-26)
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Abexinostat (Code C68920)

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Terms & Properties

Preferred Name: Abexinostat

Definition: A broad-spectrum phenyl hydroxamic acid inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis. In addition, this agent has been shown to inhibit homologous recombination (HR) activity by inhibiting the expression of RAD51. RAD51, a homologue of bacterial RecA, assists in the repair of DNA double-strand breaks (DSBs).

NCI-GLOSS Definition: A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.

Display Name: Abexinostat

Label: Abexinostat

NCI Thesaurus Code: C68920 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3537177  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-benzofurancarboxamide, 3-((dimethylamino)methyl)-n-(2-(4-((hydroxyamino)carbonyl)phenoxy)ethyl)-
3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)-1-benzofuran-2-carboxamide
Abexinostat
ABEXINOSTAT
CRA-024781
HDAC Inhibitor PCI-24781
PCI-24781

External Source Codes: 
CAS Registry Number 783355-60-2 (see NLM ChemIDplus info)
FDA UNII Code IYO470654U
PDQ Closed Trial Search ID 553625
PDQ Open Trial Search ID 553625 (check for NCI PDQ open clinical trial info)
UMLS CUI C3537177

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H23N3O5
code C68920
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name HDAC_Inhibitor_CRA-024781
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68920

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