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Version: 17.12d (Release date: 2017-12-26)
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Niacin (Code C689)

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Terms & Properties

Preferred Name: Niacin

Definition: A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C.

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Niacin helps some enzymes work properly and helps skin, nerves, and the digestive tract stay healthy. Niacin is found in many plant and animal products. It is water-soluble (can dissolve in water) and must be taken in every day. Not enough niacin can cause a disease called pellagra (a condition marked by skin, nerve, and digestive disorders). A form of niacin is being studied in the prevention of skin and other types of cancer. Niacin may help to lower blood cholesterol.

CRCH Definition: Water-soluble vitamin that is a cosubstrate or coenzyme with numerous dehydrogenases for the transfer of the hydride ion. (DRI)

Display Name: Niacin

Label: Niacin

NCI Thesaurus Code: C689 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0027996  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-Pyridinecarboxylic Acid
nicotinic acid
Nicotinic Acid
Nicotinic acid
Nicotinic Acid Amide
Vitamin B-3
Vitamin B3
vitamin B3

External Source Codes: 
CAS Registry Number 59-67-6 (see NLM ChemIDplus info)
FDA UNII Code 2679MF687A
ChEBI ID CHEBI:15940 (see ChEBI info)
NSC Code 169454 (see NCI DTP info)
PDQ Closed Trial Search ID 38351
PDQ Open Trial Search ID 38351 (check for NCI PDQ open clinical trial info)
UMLS CUI C0027996

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C6H5NO2
code C689
Contributing_Source CRCH
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Niacin
Micronutrient Y
Nutrient Y
Semantic_Type Organic Chemical
Semantic_Type Vitamin
Tolerable_Level Y
Unit mg
US_Recommended_Intake Y

Additional Concept Data: 
Defined Fully by Roles: No  


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