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Version: 17.10e (Release date: 2017-10-30)
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Abiraterone Acetate (Code C68845)

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Terms & Properties

Preferred Name: Abiraterone Acetate

Definition: An orally active acetate sester form of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.

NCI-GLOSS Definition: A substance being studied in the treatment of prostate cancer and breast cancer. It blocks tissues from making androgens (male hormones), such as testosterone. This may cause the death of cancer cells that need androgens to grow. It is a type of anti-androgen.

Display Name: Abiraterone Acetate

Label: Abiraterone Acetate

NCI Thesaurus Code: C68845 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2607886  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Abiraterone Acetate
abiraterone acetate
Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3beta)-

External Source Codes: 
CAS Registry Number 154229-18-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 552704
PDQ Open Trial Search ID 552704 (check for NCI PDQ open clinical trial info)
UMLS CUI C2607886

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Castration-resistant prostate cancer
Chemical_Formula C26H33NO2
code C68845
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Abiraterone_Acetate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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