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Version: 17.06d (Release date: 2017-06-26)
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Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514 (Code C68832)

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Terms & Properties

Preferred Name: Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514

Definition: A pyrrolotriazine-based compound and a pan inhibitor of receptor tyrosine kinases with potential antineoplastic activity. Pan HER/VEGFR2 receptor tyrosine kinase inhibitor BMS-690514 binds to human epidermal growth factor receptors (EGFR) 1, 2 and 4 (HER1, HER2 and HER4) and vascular endothelial growth factor receptor 1, 2 and 3 (VEGFR-1, -2 and -3), all of which are frequently overexpressed by a variety of tumor types. Binding of this agent to these receptors may result in the inhibition of tumor cell proliferation; the inhibition of endothelial cell migration and proliferation and angiogenesis; and tumor cell death.

Display Name: Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514

Label: Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514

NCI Thesaurus Code: C68832 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831893  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-690514
Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514

External Source Codes: 
PDQ Closed Trial Search ID 489386
PDQ Open Trial Search ID 489386 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831893

Other Properties:
     Name Value (qualifiers indented underneath)
code C68832
Contributing_Source CTRP
Legacy_Concept_Name Pan_HER_VEGFR2_Receptor_Tyrosine_Kinase_Inhibitor_BMS-690154
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68832

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