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Version: 16.11d (Release date: 2016-11-28)
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Efalizumab (Code C68831)

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Terms & Properties

Preferred Name: Efalizumab

Definition: A humanized IgG1 monoclonal antibody directed against CD11a, the alpha subunit of human leukocyte-function-associated antigen type 1 (LFA-1), with immunosuppressant activity. Efalizumab binds to CD11a, which is expressed on all leukocytes, resulting in a reduction in the cell surface expression of CD11a. In addition, this agent inhibits the binding of LFA-1 to intercellular adhesion molecule-1 (ICAM-1), resulting in the inhibition of leukocyte adherence and the suppression of cell-mediated immunity. LFA-1 binding to ICAM-1 is involved in the activation of T lymphocytes, adhesion of T lymphocytes to endothelial cells, and migration of T lymphocytes to sites of inflammation.

NCI-GLOSS Definition: A monoclonal antibody used to treat psoriasis (a chronic skin disease). It is also being studied in the treatment of graft-versus-host disease (GVHD) of the skin after a donor stem cell transplant. Efalizumab binds to a molecule called LFA-1, and blocks the action of T cells (a type of white blood cell). It is a type of immunosuppressant.

Label: Efalizumab

NCI Thesaurus Code: C68831 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1320125  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EFALIZUMAB
Efalizumab
efalizumab
Hu 1124
Raptiva
Xanelim

External Source Codes: 
CAS Registry Number 214745-43-4 (see NLM ChemIDplus info)
FDA UNII Code XX2MN88N5D
PDQ Closed Trial Search ID 553413
PDQ Open Trial Search ID 553413 (check for NCI PDQ open clinical trial info)
UMLS CUI C1320125

Other Properties:
Name Value (qualifiers indented underneath)
code C68831
Contributing_Source FDA
Legacy_Concept_Name Efalizumab
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68831

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