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Version: 17.12d (Release date: 2017-12-26)
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Efalizumab (Code C68831)

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Terms & Properties

Preferred Name: Efalizumab

Definition: A humanized IgG1 monoclonal antibody directed against CD11a, the alpha subunit of human leukocyte-function-associated antigen type 1 (LFA-1), with immunosuppressant activity. Efalizumab binds to CD11a, which is expressed on all leukocytes, resulting in a reduction in the cell surface expression of CD11a. In addition, this agent inhibits the binding of LFA-1 to intercellular adhesion molecule-1 (ICAM-1), resulting in the inhibition of leukocyte adherence and the suppression of cell-mediated immunity. LFA-1 binding to ICAM-1 is involved in the activation of T lymphocytes, adhesion of T lymphocytes to endothelial cells, and migration of T lymphocytes to sites of inflammation.

NCI-GLOSS Definition: A monoclonal antibody used to treat psoriasis (a chronic skin disease). It is also being studied in the treatment of graft-versus-host disease (GVHD) of the skin after a donor stem cell transplant. Efalizumab binds to a molecule called LFA-1, and blocks the action of T cells (a type of white blood cell). It is a type of immunosuppressant.

Label: Efalizumab

NCI Thesaurus Code: C68831 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1320125  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hu 1124

External Source Codes: 
CAS Registry Number 214745-43-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 553413
PDQ Open Trial Search ID 553413 (check for NCI PDQ open clinical trial info)
UMLS CUI C1320125

Other Properties:
     Name Value (qualifiers indented underneath)
code C68831
Contributing_Source FDA
Legacy_Concept_Name Efalizumab
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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