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Version: 17.06d (Release date: 2017-06-26)
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CHK1 Inhibitor PF-477736 (Code C68820)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: CHK1 Inhibitor PF-477736

Definition: A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects.

Display Name: CHK1 Inhibitor PF-477736

Label: CHK1 Inhibitor PF-477736

NCI Thesaurus Code: C68820 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2347279  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CHK1 Inhibitor PF-477736
PF-00477736
PF-477736

External Source Codes: 
PDQ Closed Trial Search ID 539740
PDQ Open Trial Search ID 539740 (check for NCI PDQ open clinical trial info)
UMLS CUI C2347279

Other Properties:
     Name Value (qualifiers indented underneath)
code C68820
Contributing_Source CTRP
Legacy_Concept_Name CHK1_Inhibitor_PF-477736
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68820

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