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Version: 17.06d (Release date: 2017-06-26)
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Nivolumab (Code C68814)

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Terms & Properties

Preferred Name: Nivolumab

Definition: A fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1,PCD-1,) with immune checkpoint inhibitory and antineoplastic activities. Nivolumab binds to and blocks the activation of PD-1, an Ig superfamily transmembrane protein, by its ligands programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on APCs. This results in the activation of T-cells and cell-mediated immune responses against tumor cells or pathogens. Activated PD-1 negatively regulates T-cell activation and and plays a key role in in tumor evasion from host immunity.

Display Name: Nivolumab

Label: Nivolumab

NCI Thesaurus Code: C68814 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3657270  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-936558
MDX-1106
NIVO
Nivolumab
NIVOLUMAB
ONO-4538
Opdivo

External Source Codes: 
CAS Registry Number 946414-94-4 (see NLM ChemIDplus info)
FDA UNII Code 31YO63LBSN
PDQ Closed Trial Search ID 539733
PDQ Open Trial Search ID 539733 (check for NCI PDQ open clinical trial info)
UMLS CUI C3657270

Other Properties:
     Name Value (qualifiers indented underneath)
code C68814
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-PD-1_Human_Monoclonal_Antibody_MDX-1106
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C68814

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