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Limonene (Code C68543)

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Terms & Properties

Concept Status: Retired Concept  (See:  Limonene, (+/-)- )

Preferred Name: Limonene

Definition: An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes.

CRCH Definition: A terpene with two isoprene units forming a ring. The chemical structure is CC1=CCC(CC1)C(=C)C.

Label: Limonene

NCI Thesaurus Code: C68543 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0064992  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 138-86-3 (see NLM ChemIDplus info)
UMLS CUI C0064992

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H16
code C68543
Concept_Status Retired_Concept
Contributing_Source CRCH
deprecated true
DesignNote Tue Feb 28 12:22:20 EST 2012 - See 'DL-Limonene'
Legacy_Concept_Name Limonene
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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