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Version: 17.06d (Release date: 2017-06-26)
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Zinostatin (Code C682)

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Terms & Properties

Preferred Name: Zinostatin

Definition: An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. (NCI04)

Label: Zinostatin

NCI Thesaurus Code: C682 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0027597  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
A 8544527G1
Holoneocarzinostatin
NCS
Neocarzinostatin
Vinostatin
ZINOSTATIN
Zinostatin

External Source Codes: 
CAS Registry Number 9014-02-2 (see NLM ChemIDplus info)
FDA UNII Code PP082U6W1L
NSC Code 69856 (see NCI DTP info)
NSC Code 157365 (see NCI DTP info)
PDQ Closed Trial Search ID 39510
PDQ Open Trial Search ID 39510 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 20735485 (see PubMed Primary Reference info)
UMLS CUI C0027597

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C35H35NO12
code C682
Contributing_Source FDA
Legacy_Concept_Name Zinostatin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C682

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