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Version: 17.06d (Release date: 2017-06-26)
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Naproxen (Code C680)

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Terms & Properties

Preferred Name: Naproxen

Definition: A propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of naproxen. Naproxen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

NCI-GLOSS Definition: A drug used to treat mild pain and the symptoms of arthritis and several other conditions. It is also being studied in the treatment of bone pain in patients with cancer. Naprosyn stops the body from making substances that cause pain and inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID) and a type of cyclooxygenase inhibitor.

Display Name: Naproxen

Label: Naproxen

NCI Thesaurus Code: C680 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0027396  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid
d-2-(6-Methoxy-2-naphthyl)propionic Acid
Naprosyn
Naproxen
NAPROXEN
naproxen
RS-3540

External Source Codes: 
CAS Registry Number 22204-53-1 (see NLM ChemIDplus info)
FDA UNII Code 57Y76R9ATQ
ChEBI ID CHEBI:7476 (see ChEBI info)
PDQ Closed Trial Search ID 40222
PDQ Open Trial Search ID 40222 (check for NCI PDQ open clinical trial info)
UMLS CUI C0027396

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C14H14O3
code C680
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Naproxen
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C680

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