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Version: 17.06d (Release date: 2017-06-26)
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Naltrexone Hydrochloride (Code C679)

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Terms & Properties

Preferred Name: Naltrexone Hydrochloride

Definition: The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone.

NCI-GLOSS Definition: A drug that blocks the action of opiates (drugs used to treat pain). It may be used in the treatment of intravenous opiate addiction or alcohol dependence. Naltrexone hydrochloride is also being studied in the treatment of breast cancer. It may block the effects of the hormone estrogen, which causes some breast cancer cells to grow, or block the blood flow to tumors. It is a type of opiate antagonist.

Display Name: Naltrexone Hydrochloride

Label: Naltrexone Hydrochloride

NCI Thesaurus Code: C679 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0355800  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride
Naltrexone Hydrochloride
naltrexone hydrochloride

External Source Codes: 
CAS Registry Number 16676-29-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 40818
PDQ Open Trial Search ID 40818 (check for NCI PDQ open clinical trial info)
UMLS CUI C0355800

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H23NO4.HCl
code C679
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Naltrexone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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