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Version: 17.12d (Release date: 2017-12-26)
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Naloxone Hydrochloride (Code C678)

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Terms & Properties

Preferred Name: Naloxone Hydrochloride

Definition: The hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity. Naloxone binds to opioid receptors in the CNS in a competitive manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. This agent binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors.

Label: Naloxone Hydrochloride

NCI Thesaurus Code: C678 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0684237  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Naloxone Hydrochloride

External Source Codes: 
CAS Registry Number 357-08-4 (see NLM ChemIDplus info)
FDA UNII Code F850569PQR
NSC Code 70413 (see NCI DTP info)
PDQ Closed Trial Search ID 39509
PDQ Open Trial Search ID 39509 (check for NCI PDQ open clinical trial info)
UMLS CUI C0684237

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H21NO4.HCl
code C678
Contributing_Source FDA
Legacy_Concept_Name Naloxone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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