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Version: 16.11d (Release date: 2016-11-28)
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Liposomal Cytarabine-Daunorubicin CPX-351 (Code C67504)

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Terms & Properties

Preferred Name: Liposomal Cytarabine-Daunorubicin CPX-351

Definition: A liposomal formulation containing a fixed combination of the antineoplastic agents cytarabine and daunorubicin in a 5:1 molar ratio. Liposomal cytarabine-daunorubicin CPX-351 has been designed to provide optimal delivery of a specific ratio of cytarabine to daunorubicin, one that has been shown to be synergistic in vitro. The antimetabolite cytarabine competes with cytidine for incorporation into DNA, inhibiting DNA synthesis. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Daunorubicin, an intercalator and a topoisomerase II inhibitor, prevents DNA replication and inhibits protein synthesis. This agent also generates oxygen free radicals, resulting in the cytotoxic lipid peroxidation of cell membrane lipids.

Display Name: Liposomal Cytarabine-Daunorubicin CPX-351

Label: Liposomal Cytarabine-Daunorubicin CPX-351

NCI Thesaurus Code: C67504 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL372099  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CPX-351
Cytarabine-Daunorubicin Liposome for Injection
Liposomal AraC-Daunorubicin CPX-351
Liposomal Cytarabine-Daunorubicin CPX-351

External Source Codes: 
PDQ Closed Trial Search ID 554979
PDQ Open Trial Search ID 554979 (check for NCI PDQ open clinical trial info)
NCI META CUI CL372099

Other Properties:
Name Value (qualifiers indented underneath)
code C67504
Contributing_Source CTRP
Legacy_Concept_Name Liposomal_Cytarabine-Daunorubicin_CPX-351
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67504

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