|Baclofen/Amitriptyline/Ketamine Gel (Code C67261)|
|Terms & Properties|
Preferred Name: Baclofen/Amitriptyline/Ketamine Gel
Definition: A topical preparation of baclofen, amitriptyline, and ketamine compounded in a penetration-enhancing polaxamer-lecithin organogel (PLO) with potential antineuralgic activity. The gamma-aminobutyric acid (GABA) analogue baclofen appears to activate the inhibitory GABA(B) receptor, a G protein-coupled receptor, which may result in hyperpolarization of the neuronal cell membrane and inhibition of neurotransmitter release. Amitriptyline likely produces antineuralgic effects via modulation of multiple subtypes of glutamate (Glu) receptors, independent of its antidepressant actions. Ketamine displays complex pharmacologic actions including biogenic amine uptake inhibition, interaction with opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Stimulation of GABA(B) receptor activity, modulation of Glu receptor activity, and inhibition of NMDA receptor activity may be of benefit in managing neuropathic pain.
NCI-GLOSS Definition: A substance being studied in the treatment of peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) caused by chemotherapy. It contains three drugs, baclofen, amitriptyline, and ketamine, that relax muscles by blocking nerve receptors. The gel is applied to the skin of affected areas. It is a type of analgesic.
Label: Baclofen/Amitriptyline/Ketamine Gel
NCI Metathesaurus Link: C1879777 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|PDQ Closed Trial Search ID||561347|
|PDQ Open Trial Search ID||561347 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|