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Version: 16.11d (Release date: 2016-11-28)
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Baclofen/Amitriptyline/Ketamine Gel (Code C67261)

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Terms & Properties

Preferred Name: Baclofen/Amitriptyline/Ketamine Gel

Definition: A topical preparation of baclofen, amitriptyline, and ketamine compounded in a penetration-enhancing polaxamer-lecithin organogel (PLO) with potential antineuralgic activity. The gamma-aminobutyric acid (GABA) analogue baclofen appears to activate the inhibitory GABA(B) receptor, a G protein-coupled receptor, which may result in hyperpolarization of the neuronal cell membrane and inhibition of neurotransmitter release. Amitriptyline likely produces antineuralgic effects via modulation of multiple subtypes of glutamate (Glu) receptors, independent of its antidepressant actions. Ketamine displays complex pharmacologic actions including biogenic amine uptake inhibition, interaction with opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Stimulation of GABA(B) receptor activity, modulation of Glu receptor activity, and inhibition of NMDA receptor activity may be of benefit in managing neuropathic pain.

NCI-GLOSS Definition: A substance being studied in the treatment of peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) caused by chemotherapy. It contains three drugs, baclofen, amitriptyline, and ketamine, that relax muscles by blocking nerve receptors. The gel is applied to the skin of affected areas. It is a type of analgesic.

Label: Baclofen/Amitriptyline/Ketamine Gel

NCI Thesaurus Code: C67261 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1879777  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Baclofen/Amitriptyline/Ketamine Gel
baclofen/amitriptyline/ketamine gel
BAK Gel
BAK gel

External Source Codes: 
PDQ Closed Trial Search ID 561347
PDQ Open Trial Search ID 561347 (check for NCI PDQ open clinical trial info)
UMLS CUI C1879777

Other Properties:
Name Value (qualifiers indented underneath)
code C67261
Legacy_Concept_Name Baclofen_Amitriptyline_Ketamine_Gel
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67261

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