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Version: 17.12d (Release date: 2017-12-26)
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Ketamine/Amitriptyline NP-H Cream (Code C67250)

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Terms & Properties

Preferred Name: Ketamine/Amitriptyline NP-H Cream

Definition: A topical preparation containing the antidepressant amitriptyline and the excitatory amino acid antagonist ketamine with potential topical analgesic activity. In addition to activating adenosine A1 receptors and inhibiting the neuronal reuptake of norepinephrine and serotonin, amitriptyline produces antinociceptive effects, which appear to be mediated through the modulation of multiple subtypes of glutamate receptors including the N-methyl D-aspartate (NMDA) receptor. Ketamine inhibits biogenic amine uptake, agonistically binds to mu-opioid receptors, and inhibits NMDA receptors. NDMA receptor antagonists such as amitriptyline and ketamine interfere with the role of NMDA receptors in the process of central sensitization in which NMDA receptors on spinal dorsal horn neurons are activated, resulting in an increase in synaptic efficacy and so an amplification of the response to sensory input.

Display Name: Ketamine/Amitriptyline NP-H Cream

Label: Ketamine/Amitriptyline NP-H Cream

NCI Thesaurus Code: C67250 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1881304  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EpiCept-NP-H Cream
Ketamine 2%/Amitriptyline 4% Cream
Ketamine/Amitriptyline NP-H Cream

External Source Codes: 
NSC Code 744013 (see NCI DTP info)
PDQ Closed Trial Search ID 547044
PDQ Open Trial Search ID 547044 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 16202956 (see PubMed Primary Reference info)
UMLS CUI C1881304

Other Properties:
     Name Value (qualifiers indented underneath)
code C67250
Contributing_Source CTRP
Legacy_Concept_Name Ketamine_Amitriptyline_NP-H_Cream
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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