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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Oral Sodium Phenylbutyrate (Code C67083)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oral Sodium Phenylbutyrate

Definition: An orally active derivative of the short-chain fatty acid butyrate with potential antineoplastic activity. 4-Phenylbutyrate inhibits histone deacetylase, resulting in cell cycle gene expression modulation, reduced cell proliferation, increased cell differentiation, and apoptosis. This agent also initiates fragmentation of genomic DNA, resulting in decreased DNA synthesis and the inhibition of tumor cell migration and invasion.

Display Name: Oral Sodium Phenylbutyrate

Label: Oral Sodium Phenylbutyrate

NCI Thesaurus Code: C67083 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1882164  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oral Sodium Phenylbutyrate

External Source Codes: 
PDQ Closed Trial Search ID 41827
PDQ Open Trial Search ID 41827 (check for NCI PDQ open clinical trial info)
UMLS CUI C1882164

Other Properties:
     Name Value (qualifiers indented underneath)
code C67083
Contributing_Source CTRP
Legacy_Concept_Name Oral_Sodium_Phenylbutyrate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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