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Version: 16.11d (Release date: 2016-11-28)
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Remestemcel-L (Code C67082)

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Terms & Properties

Preferred Name: Remestemcel-L

Definition: Human mesenchymal stem cells (MSCs) harvested from bone marrow of healthy adult donors and expanded ex vivo, with potential immunosuppressive application. Allogeneic adult MSCs are hypo-immunogenic due to lack of major histocompatibility II (MHC II) molecule expression, and thereby elicit none or minimal immune response upon intravenous infusion. MSCs are pluripotent, and are capable of being recruited to damaged tissue sites and differentiating along specific lineages when stimulated. Infusion of MSCs results in: a) increased production of anti-inflammatory cytokines, such as interleukin-10, prostaglandin E, and hepatocyte growth factor; b) decreased mononuclear phagocyte expression of indoleamine 2,3,-dioxygenase, which catabolizes L-tryptophan into its metabolites, which in turn contribute to inflammation; and c) modulated dendritic cell maturation and disrupted activities of natural killer cells, CD8+ and CD4+ T cells.

Display Name: Remestemcel-L

Label: Remestemcel-L

NCI Thesaurus Code: C67082 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1879680  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic Adults MSCs
Allogeneic Adult Mesenchymal Stem Cells
JR-0301
Prochymal
Remestemcel-L

External Source Codes: 
PDQ Closed Trial Search ID 537395
PDQ Open Trial Search ID 537395 (check for NCI PDQ open clinical trial info)
UMLS CUI C1879680

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Immunomodulator, anti-inflammatory, tissue protectant
code C67082
Contributing_Source CTRP
Legacy_Concept_Name Allogeneic_Expanded_Mesenchymal_Stem_Cells
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67082

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