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Version: 17.06d (Release date: 2017-06-26)
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Rilotumumab (Code C67079)

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Terms & Properties

Preferred Name: Rilotumumab

Definition: A fully human IgG2 monoclonal antibody directed against the human hepatocyte growth factor (HGF) with potential antineoplastic activity. Anti-HGF monoclonal antibody AMG 102 binds to and neutralizes HGF, preventing the binding of HGF to its receptor c-Met and so c-Met activation; inhibition of c-Met-mediated signal transduction may result in the induction of apoptosis in cells expressing c-Met. c-Met (HGF receptor or HGFR), a receptor tyrosine kinase overexpressed or mutated in a variety of epithelial cancer cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It binds to a protein called hepatocyte growth factor (HGF), which may cause cancer cells to grow. Blocking this may cause cancer cells to die. AMG 102 is a type of monoclonal antibody.

Display Name: Rilotumumab

Label: Rilotumumab

NCI Thesaurus Code: C67079 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2743963  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG 102
Anti-HGF Monoclonal Antibody AMG 102
anti-HGF monoclonal antibody AMG 102
Fully Human Anti-HGF Monoclonal Antibody AMG 102

External Source Codes: 
CAS Registry Number 872514-65-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 536240
PDQ Open Trial Search ID 536240 (check for NCI PDQ open clinical trial info)
UMLS CUI C2743963

Other Properties:
     Name Value (qualifiers indented underneath)
code C67079
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-HGF_Monoclonal_Antibody_AMG_102
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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