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Version: 17.06d (Release date: 2017-06-26)
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Rilotumumab (Code C67079)

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Terms & Properties

Preferred Name: Rilotumumab

Definition: A fully human IgG2 monoclonal antibody directed against the human hepatocyte growth factor (HGF) with potential antineoplastic activity. Anti-HGF monoclonal antibody AMG 102 binds to and neutralizes HGF, preventing the binding of HGF to its receptor c-Met and so c-Met activation; inhibition of c-Met-mediated signal transduction may result in the induction of apoptosis in cells expressing c-Met. c-Met (HGF receptor or HGFR), a receptor tyrosine kinase overexpressed or mutated in a variety of epithelial cancer cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It binds to a protein called hepatocyte growth factor (HGF), which may cause cancer cells to grow. Blocking this may cause cancer cells to die. AMG 102 is a type of monoclonal antibody.

Display Name: Rilotumumab

Label: Rilotumumab

NCI Thesaurus Code: C67079 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2743963  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG 102
Anti-HGF Monoclonal Antibody AMG 102
anti-HGF monoclonal antibody AMG 102
Fully Human Anti-HGF Monoclonal Antibody AMG 102
Rilotumumab
RILOTUMUMAB

External Source Codes: 
CAS Registry Number 872514-65-3 (see NLM ChemIDplus info)
FDA UNII Code 51WEW898IJ
PDQ Closed Trial Search ID 536240
PDQ Open Trial Search ID 536240 (check for NCI PDQ open clinical trial info)
UMLS CUI C2743963

Other Properties:
     Name Value (qualifiers indented underneath)
code C67079
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-HGF_Monoclonal_Antibody_AMG_102
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67079

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