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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Cell Cycle Checkpoint/DNA Repair Antagonist IC83 (Code C67075)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cell Cycle Checkpoint/DNA Repair Antagonist IC83

Definition: A proprietary agent with potential antineoplastic activity. IC83 appears to target cell cycle checkpoint/DNA repair enzymes, which are involved in the recognition and repair of damaged DNA and are overexpressed in many types of cancer cells. Inhibition of cell cycle checkpoint/DNA repair enzymes may enhance the cytotoxicity of DNA damaging agents and dissipate tumor cell resistance to chemotherapy and radiation therapy.

Display Name: Cell Cycle Checkpoint/DNA Repair Antagonist IC83

Label: Cell Cycle Checkpoint/DNA Repair Antagonist IC83

NCI Thesaurus Code: C67075 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1881108  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cell Cycle Checkpoint/DNA Repair Antagonist IC83
IC83

External Source Codes: 
PDQ Closed Trial Search ID 536220
PDQ Open Trial Search ID 536220 (check for NCI PDQ open clinical trial info)
UMLS CUI C1881108

Other Properties:
     Name Value (qualifiers indented underneath)
code C67075
Contributing_Source CTRP
Legacy_Concept_Name IC83
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67075

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